Newsgroups: alt.psychoactives From: bwhite@oucsace.cs.ohiou.edu (William E. White ) Subject: Re: Special K = PCP Message-ID: Date: Sat, 1 Oct 1994 02:09:09 GMT In article <35q1ek$i9o@explorer.clark.net>, Murple wrote: > >Although PCP and Ketamine have virtually identical effects, they are 2 >different drugs. I'd like to point out that most NMDA/sigma agents (of which PCP and ketamine are two) tend to have fairly individual patterns of affinity and activity on their targets (which include at least two sigma receptor types, at least two and probably three NMDA receptor sites, one reuptake site, and probably a couple of others). Having tried neither PCP nor ketamine (and not having the desire to try either), I wouldn't know for sure, but I would bet there would be some difference between the two, given that they do exhibit subtly different activity and affinity spectra. Incidentally, MK-801 (dizocilipine? or something like that), which is another of the same class of NMDA/sigma agents, should have a similar set of effects. MK-801 is being investigaged for its neuroprotective effects (against excitotoxicity from endogenous quinolinic acid and other assaults); PCP and ketamine should have the same abilities, but somehow I don't see many patients reacting positively to "well, we'd like to dose you with PCP to cut down on brain damage from that head injury". >Ketamine is still used in veterinary medicine, but I'm not >sure if it is used in humans...although it is legal for medical use, as >far as I know. Several times when this topic has come up, it has been mentioned that ketamine is used as an anaesthetic in severe burn victims. Why this is, I don't know. -- | Bill White +1-614-594-3434 | bwhite@oucsace.cs.ohiou.edu | | 44 Canterbury, Athens OH 45701 | finger for PGP2.2 block | Newsgroups: alt.drugs From: spogue@oucsace.cs.ohiou.edu (Yazmar the UnClean) Subject: Re: Research information Message-ID: Date: Thu, 9 Jun 1994 06:40:57 GMT MK-801 is a drug in the PCP/ketamine family. Quite a bit more potent than both. I've never heard of it being being used as a 'recreational' psychedelic however. I keep running across references to it while searching for ketamine articles on medline. Yaz ---------- Forwarded message ---------- Date: Wed, 17 May 1995 17:32:27 -0700 From: Steven K. Gill Subject: MK-801 Recently, upon indulging my curiosity on what files hyperreal.com had under "dissociative anaesthetics", I noticed MK-801 (dizocilpine) listed along with ketamine, pcp, etc. The former is not an anaesthetic, and does not induce the entheogenic states typical of ketamine. See, for example Physiol. & Behavior, *54*, 547 (1993), Pharmacology, Biochemistry & Behavior, *48*, 935, (1994), and Neuropsychopharmacology *11*, 167, (1994). In all three papers, the lack of pcp-like anaesthesia with MK-801 is mentioned, and it is further pointed out that blockade of NMDA receptors alone is not the mechanism of action of dissociative anaesthetics. Of course it is well known that the latter strongly affect sigma endorphin receptors, and DA receptors as well. MK-801 is relatively free of these effects, thus listing MK-801 with ketamine is misleading, to say the least. If you wish to list other dissociative agents, you should certainly include tiletamine, the N-ethyl, thienyl analog of ketamine. In admixture with a benzodiazepine, it is known as Telazol, and is used as an animal anaesthetic. Hopefully this information has been of possible utility.. Respectfully, S ..